Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1a) docking protein
نویسندگان
چکیده
Tony Ferrar*, Delphine Chamousset*, Veerle De Wever, Mhairi Nimick, Jens Andersen, Laura Trinkle-Mulcahy and Greg B. G. Moorhead Department of Biological Sciences, University of Calgary, 2500 University Dr, Calgary, Alberta, T2N 1N4, Canada Department of Cellular & Molecular Biology and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada Department of Biochemistry & Molecular Biology, University of Southern Denmark, Odense, 55 DK 5230, Denmark
منابع مشابه
Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein
The promiscuous activity of protein phosphatase one (PP1) is controlled in the cell by associated proteins termed regulatory or targeting subunits. Using biochemical and proteomic approaches we demonstrate that the autosomal recessive nonsyndromic hearing loss gene, taperin (C9orf75), encodes a protein that preferentially docks the alpha isoform of PP1. Taperin associates with PP1 through a cla...
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